Controlling the kinetics of interferon transgene expression for improved gene therapy
نویسندگان
چکیده
منابع مشابه
Promoter Attenuation in Gene Therapy: Interferon-y and Tumor Necrosis Factor-a Inhibit Transgene Expression
One of the major limitations to current gene therapy is the low-level and transient vector gene expression due to poorly defined mechanisms, possibly including promoter attenuation or extinction. Because the application of gene therapy vectors in vivo induces cytokine production through specific or nonspecific i m m u n e responses, w e hypothesized that cytokine-mediated signals m a y alter ve...
متن کاملMicroRNA-regulated transgene expression systems for gene therapy and virotherapy.
For safe and effective gene therapy, targeted tissue-restricted transgene expression is desirable. Various methods have been developed to achieve such expression, including the use of tissue-specific promoters. In addition to these approaches, a new system which can regulate transgene expression, including viral gene expression, by exploiting microRNAs (miRNAs) has recently been developed. miRN...
متن کاملA Heat-Inducible Transgene Expression System for Gene Therapy
Heat-inducible gene expression vectors are useful for hyperthermia-induced cancer gene therapy, because the combination of hyperthermia and gene therapy can considerably improve the therapeutic effects. In the present study, we developed an enhanced heat-inducible transgene expression system in which a heat-shock protein (HSP) promoter and tetracycline-responsive transactivator were combined. W...
متن کاملDeath switch for gene therapy: application to erythropoietin transgene expression.
The effectiveness of the caspase-9-based artificial "death switch" as a safety measure for gene therapy based on the erythropoietin (Epo) hormone was tested in vitro and in vivo using the chemical inducer of dimerization, AP20187. Plasmids encoding the dimeric murine Epo, the tetracycline-controlled transactivator and inducible caspase 9 (ptet-mEpoD, ptet-tTAk and pSH1/Sn-E-Fv'-Fvls-casp9-E, re...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Drug Targeting
سال: 2012
ISSN: 1061-186X,1029-2330
DOI: 10.3109/1061186x.2012.716848